Liraglutide half-life and pharmacokinetics chart
Pre-filled plasma half-life model for Liraglutide. See how a 13 hours half-life affects steady state, accumulation, peak-trough swing, and clearance timing.
Preset values: 3000 mcg every day, half-life ~13 hours.
Short half-life (~13h) is why liraglutide requires daily injection, unlike its weekly successors.
Open interactive chart →Why these values?
The half-life used here (13 hours) is the published or well-established estimate for Liraglutide from pharmacokinetic studies. The default dose (3000 mcg) and cadence (every day) reflect typical standard protocols — not a prescription or recommendation. Your specific product's label and your clinician's protocol override any default here.
Accumulation. With a half-life of 13 hours and dosing every day, the ratio τ/t½ = 1.85 gives an accumulation factor of ~1.39×. That means the steady-state peak plasma mass is about 1.4× the mass of a single dose.
Time to steady state. Approximately 5 half-lives (~2.7 days) of consistent dosing before average concentration stops rising. Dose-escalation protocols that change doses before this point are titrating against a still-rising baseline, which is one reason weekly peptides feel "slow" at the start.
How long does Liraglutide stay in your system?
After a single dose, half of the Liraglutide is gone in about 13 hours, 97% is cleared in about 2.7 days (five half-lives), and under 1% remains after about 3.6 days.
| Cleared | Remaining | Half-lives | Time after one Liraglutide dose |
|---|---|---|---|
| 50% | 50% | 1 | 13 hours |
| 75% | 25% | 2 | 26 hours |
| 90% | 10% | 3.3 | 43 hours |
| 97% | 3% | 5.1 | 2.7 days |
| 99% | 1% | 6.6 | 3.6 days |
Between doses. At every day, doses land 1.85 half-lives apart, so about 28% of the peak is still present when the next dose goes in. The steady-state swing in this model runs from ~4156 mcg at peak to ~1156 mcg at trough — a moderate swing with meaningful carry-over from one dose to the next.
A first-order, one-compartment model: it leaves out absorption delay from the injection depot, protein binding and individual differences in clearance, and effects can outlast plasma levels. Good for dosing rhythm; not clinical pharmacokinetics.
Liraglutide half-life FAQ
What is the plasma half-life of Liraglutide?
This chart uses an estimated Liraglutide plasma half-life of about 13 hours. Published values can vary by formulation, route, assay, and study design.
How long until Liraglutide reaches steady state?
A simple first-order model reaches practical steady state after about five half-lives, which is roughly 2.7 days for Liraglutide.
How long does Liraglutide stay in your system?
After a single dose, half of the Liraglutide is gone in about 13 hours, 97% is cleared in about 2.7 days (five half-lives), and under 1% remains after about 3.6 days. Those are plasma estimates from a half-life of 13 hours; effects can outlast plasma levels, and detection windows depend on the assay.
How much Liraglutide is left when the next dose is due?
Dosing every day is 1.85 half-lives apart, so about 28% of the peak level remains at the next dose. At steady state that means a peak of ~4156 mcg and a trough of ~1156 mcg in the model.
Does this Liraglutide pharmacokinetics chart recommend a dosing schedule?
No. It visualizes half-life, accumulation, peaks, and troughs from values you enter. It is not a prescription, dose recommendation, or substitute for the product label or clinician guidance.
Why does steady state matter for Liraglutide?
Steady state explains why long-half-life compounds can keep rising for weeks after starting or changing a dose, while short-half-life compounds behave more like brief pulses.
Related for Liraglutide
Half-life charts for related peptides: Survodutide (7 days), Retatrutide (6 days), Semaglutide (7 days), Tirzepatide (5 days).
Track your real Liraglutide protocol
Peptide Protocol logs every actual injection time and shows your real timeline — not a model. Side-effect tracking included.
Get the iPhone app →Educational use only. Nothing on this page constitutes medical advice. Pharmacokinetic parameters are published estimates; individual PK varies. Use label values and consult a clinician for any dosing decision.
Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.