MOTS-c half-life and pharmacokinetics chart
Pre-filled plasma half-life model for MOTS-c. See how a 2 hours half-life affects steady state, accumulation, peak-trough swing, and clearance timing.
Preset values: 5000 mcg every 3 days, half-life ~2 hours.
Mitochondrial peptide with short plasma half-life; protocols commonly dose 3× per week.
Open interactive chart →Why these values?
The half-life used here (2 hours) is the published or well-established estimate for MOTS-c from pharmacokinetic studies. The default dose (5000 mcg) and cadence (every 3 days) reflect typical standard protocols — not a prescription or recommendation. Your specific product's label and your clinician's protocol override any default here.
Accumulation. With a half-life of 2 hours and dosing every 3 days, the ratio τ/t½ = 36.00 gives an accumulation factor of ~1.00×. That means the steady-state peak plasma mass is about 1.0× the mass of a single dose.
Time to steady state. Approximately 5 half-lives (~0.4 days) of consistent dosing before average concentration stops rising. Dose-escalation protocols that change doses before this point are titrating against a still-rising baseline, which is one reason weekly peptides feel "slow" at the start.
How long does MOTS-c stay in your system?
After a single dose, half of the MOTS-c is gone in about 2 hours, 97% is cleared in about 10 hours (five half-lives), and under 1% remains after about 13 hours.
| Cleared | Remaining | Half-lives | Time after one MOTS-c dose |
|---|---|---|---|
| 50% | 50% | 1 | 2 hours |
| 75% | 25% | 2 | 4 hours |
| 90% | 10% | 3.3 | 6.6 hours |
| 97% | 3% | 5.1 | 10 hours |
| 99% | 1% | 6.6 | 13 hours |
Between doses. At every 3 days, doses land 36.00 half-lives apart, so about <0.1% of the peak is still present when the next dose goes in. The steady-state swing in this model runs from ~5000 mcg at peak to ~<0.1 mcg at trough — a pulse that mostly clears before the next injection, so MOTS-c does not build up much at this cadence.
A first-order, one-compartment model: it leaves out absorption delay from the injection depot, protein binding and individual differences in clearance, and effects can outlast plasma levels. Good for dosing rhythm; not clinical pharmacokinetics.
MOTS-c half-life FAQ
What is the plasma half-life of MOTS-c?
This chart uses an estimated MOTS-c plasma half-life of about 2 hours. Published values can vary by formulation, route, assay, and study design.
How long until MOTS-c reaches steady state?
A simple first-order model reaches practical steady state after about five half-lives, which is roughly 10 hours for MOTS-c.
How long does MOTS-c stay in your system?
After a single dose, half of the MOTS-c is gone in about 2 hours, 97% is cleared in about 10 hours (five half-lives), and under 1% remains after about 13 hours. Those are plasma estimates from a half-life of 2 hours; effects can outlast plasma levels, and detection windows depend on the assay.
How much MOTS-c is left when the next dose is due?
Dosing every 3 days is 36.00 half-lives apart, so about <0.1% of the peak level remains at the next dose. At steady state that means a peak of ~5000 mcg and a trough of ~<0.1 mcg in the model.
Does this MOTS-c pharmacokinetics chart recommend a dosing schedule?
No. It visualizes half-life, accumulation, peaks, and troughs from values you enter. It is not a prescription, dose recommendation, or substitute for the product label or clinician guidance.
Why does steady state matter for MOTS-c?
Steady state explains why long-half-life compounds can keep rising for weeks after starting or changing a dose, while short-half-life compounds behave more like brief pulses.
Related for MOTS-c
Half-life charts for related peptides: AOD-9604 (2 hours), Cagrilintide (7.5 days), Epithalon (30 minutes), Liraglutide (13 hours).
Track your real MOTS-c protocol
Peptide Protocol logs every actual injection time and shows your real timeline — not a model. Side-effect tracking included.
Get the iPhone app →Educational use only. Nothing on this page constitutes medical advice. Pharmacokinetic parameters are published estimates; individual PK varies. Use label values and consult a clinician for any dosing decision.
Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.