Sermorelin half-life and pharmacokinetics chart
Pre-filled plasma half-life model for Sermorelin. See how a 12 minutes half-life affects steady state, accumulation, peak-trough swing, and clearance timing.
Preset values: 200 mcg every day, half-life ~12 minutes.
10–15 min half-life. Each evening injection produces a brief GHRH pulse; no accumulation between doses.
Open interactive chart →Why these values?
The half-life used here (12 minutes) is the published or well-established estimate for Sermorelin from pharmacokinetic studies. The default dose (200 mcg) and cadence (every day) reflect typical standard protocols — not a prescription or recommendation. Your specific product's label and your clinician's protocol override any default here.
Accumulation. With a half-life of 12 minutes and dosing every day, the ratio τ/t½ = 120.00 gives an accumulation factor of ~1.00×. That means the steady-state peak plasma mass is about 1.0× the mass of a single dose.
Time to steady state. Approximately 5 half-lives (~0.0 days) of consistent dosing before average concentration stops rising. Dose-escalation protocols that change doses before this point are titrating against a still-rising baseline, which is one reason weekly peptides feel "slow" at the start.
How long does Sermorelin stay in your system?
After a single dose, half of the Sermorelin is gone in about 12 minutes, 97% is cleared in about 1 hours (five half-lives), and under 1% remains after about 1.3 hours.
| Cleared | Remaining | Half-lives | Time after one Sermorelin dose |
|---|---|---|---|
| 50% | 50% | 1 | 12 minutes |
| 75% | 25% | 2 | 24 minutes |
| 90% | 10% | 3.3 | 40 minutes |
| 97% | 3% | 5.1 | 1 hours |
| 99% | 1% | 6.6 | 1.3 hours |
Between doses. At every day, doses land 120.00 half-lives apart, so about <0.1% of the peak is still present when the next dose goes in. The steady-state swing in this model runs from ~200 mcg at peak to ~<0.1 mcg at trough — a pulse that mostly clears before the next injection, so Sermorelin does not build up much at this cadence.
A first-order, one-compartment model: it leaves out absorption delay from the injection depot, protein binding and individual differences in clearance, and effects can outlast plasma levels. Good for dosing rhythm; not clinical pharmacokinetics.
Sermorelin half-life FAQ
What is the plasma half-life of Sermorelin?
This chart uses an estimated Sermorelin plasma half-life of about 12 minutes. Published values can vary by formulation, route, assay, and study design.
How long until Sermorelin reaches steady state?
A simple first-order model reaches practical steady state after about five half-lives, which is roughly 1 hours for Sermorelin.
How long does Sermorelin stay in your system?
After a single dose, half of the Sermorelin is gone in about 12 minutes, 97% is cleared in about 1 hours (five half-lives), and under 1% remains after about 1.3 hours. Those are plasma estimates from a half-life of 12 minutes; effects can outlast plasma levels, and detection windows depend on the assay.
How much Sermorelin is left when the next dose is due?
Dosing every day is 120.00 half-lives apart, so about <0.1% of the peak level remains at the next dose. At steady state that means a peak of ~200 mcg and a trough of ~<0.1 mcg in the model.
Does this Sermorelin pharmacokinetics chart recommend a dosing schedule?
No. It visualizes half-life, accumulation, peaks, and troughs from values you enter. It is not a prescription, dose recommendation, or substitute for the product label or clinician guidance.
Why does steady state matter for Sermorelin?
Steady state explains why long-half-life compounds can keep rising for weeks after starting or changing a dose, while short-half-life compounds behave more like brief pulses.
Related for Sermorelin
Half-life charts for related peptides: GHRP-2 (15 minutes), GHRP-6 (30 minutes), CJC-1295 (8 days), Hexarelin (1 hour).
Track your real Sermorelin protocol
Peptide Protocol logs every actual injection time and shows your real timeline — not a model. Side-effect tracking included.
Get the iPhone app →Educational use only. Nothing on this page constitutes medical advice. Pharmacokinetic parameters are published estimates; individual PK varies. Use label values and consult a clinician for any dosing decision.
Educational use only. Peptide Protocol is an informational tool. Nothing on this page constitutes medical advice. Many peptides are prescription-only or restricted in your jurisdiction. Always consult a licensed healthcare professional before injecting any compound.